Article
Genetic basis of the circle of Willis characteristics in the healthy and intracranial aneurysm population.
European journal of human genetics : EJHG - 1 Jun 2026
Bakker Mark K, Groenheide Phebe J, Vos Iris N, Lin Qi Chang, Nanninga Marloes H A, Guzu Alina, Paic Barbara, Verhoeff Tessa A, Bekema Erwin, Teumer Alexander, Bülow Robin, Völker Uwe, Völzke Henry, Grabe Hans J, Kuijf Hugo J, Velthuis Birgitta K, Veldink Jan H, Ruigrok Ynte M
Abstract excerpt
Rupture of an intracranial aneurysm (IA) can result in aneurysmal subarachnoid hemorrhage (ASAH), a severe and often fatal form of stroke. The configuration of the intracranial arteries - collectively known as the circle of Willis (CoW) - influences the risk of IA development and rupture. Although CoW variation is known to be heritable, its genetic underpinnings and contribution to IA remain poorly understood....
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