Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2).

Clinical pharmacology and therapeutics - 1 Jul 2025

Riselli Andrew M, Yee Sook Wah, Yang Jia, Brett Claire M, Trumbach Kelsey, Zhou Xujia, Liu Renmeng, Liang Xiaomin, Lai Yurong, Huo Runlan, Xue Yongjun, Shen Hong, Zhang Lei, Yang Xinning, Liu Qi, Huang Shiew-Mei, Giacomini Kathleen M

Abstract excerpt

Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans. A comprehensive analysis of metabolomic genome-wide association studies (mGWAS) was conducted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Interactions

Share to CP gene

Share to Genome-Wide Association Study

Share to Neoplasm Proteins

Share to Polymorphism, Single Nucleotide

Share to Rosuvastatin Calcium

Source

Open in PubMed Open full text

Identifiers

PMID: 40170495
DOI: 10.1002/cpt.3657
PMCID: PMC12166265

Genes

ABCG2
CP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2).PMID 40170495Read ↗

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.Semantic proximity Read ↗

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)Semantic proximity Read ↗

BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications.Semantic proximity Read ↗

Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics.Semantic proximity Read ↗

Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2Semantic proximity Read ↗

Functional SNPs of the breast cancer resistance protein-therapeutic effects and inhibitor development.Semantic proximity Read ↗

Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug ResponseSemantic proximity Read ↗

Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.Semantic proximity Read ↗

Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics.Semantic proximity Read ↗

Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2).Semantic proximity Read ↗

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid.Semantic proximity Read ↗

In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.