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Article

An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma

1 Apr 2025

Abstract excerpt

Disease progression is a substantial challenge in patients with non-Hodgkin lymphoma (NHL) undergoing chimeric antigen receptor T cell (CAR-T) therapy. Here we present InflaMix (INFLAmmation MIXture Model), an unsupervised quantitative model integrating 14 pre-CAR-T infusion laboratory and cytokine measures capturing inflammation and end-organ function. Developed using a cohort of 149 patients with NHL, InflaMix...

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PMID: 40169864
DOI: 10.1038/s41591-025-03532-x

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