Article

Coordinated expansion of CD163⁺ monocytes and immature CD177⁺ neutrophils marks severe neurotoxicity after CD19 CAR T cell therapy

2026-07-09

Abstract excerpt

<h4>ABSTRACT</h4> Immune effector cell-associated neurotoxicity syndrome (ICANS) is a major complication after CAR T cell therapy, but its underlying mechanisms remain poorly understood. We performed longitudinal immune profiling of paired whole blood and serum samples from patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL) treated with CD19 CAR T cells. At peak neurotoxicity, high-dimensi...

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Literature Corpus work: 3850001d-6b99-554c-947e-ac4d8fcc5c89
DOI: 10.64898/2026.07.07.737099

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