Article

Further modification of the EASIX score through the addition of phosphorous and IL-6 improves prediction of CRS and ICANS after CAR-T therapy

2024-07-22

Abstract excerpt

<title>Abstract</title> <p>Cytokine release syndrome (CRS) and immune cell-associated neurotoxicity syndrome (ICANS) are severe complications of CAR-T therapy linked to endothelial dysfunction. The modified Endothelial Activation and Stress Index (m-EASIX) score predicts severe ICANS and CRS. Both hypophosphatemia and elevated IL-6 are associated with these syndromes. Our study aimed to improve early prediction b...

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Literature Corpus work: 2314c0e2-932e-5f72-941f-b923b5628073
DOI: 10.21203/rs.3.rs-4650639/v1

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