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C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation

31 Mar 2025

Abstract excerpt

In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional inactivation remain poorly understood. SETD8 is the sole enzyme known to mono-methylate p53 on lysine 382 (p53K382me1), resulting in the inhibition of its pro-apoptotic and growth-arresting functions. We analyzed SETD8 and p53K382me1 expression in clinical colorectal cancer (CRC)...

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PMID: 40165182
DOI: 10.1186/s12943-025-02293-y

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