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Article

Cell-autonomous dysregulation of interferon signaling drives clonal expansion of SRSF2-mutant MDS stem/progenitor cells.

Blood - 3 Jul 2025

Takashima Kouhei, Olszewska Malgorzata, Jethalia Vrinda, Sirenko Maria, Silverman Lewis, Tomalin Lewis E, Carcamo Saul, Hasson Dan, Papapetrou Eirini P

Abstract excerpt

ABSTRACT: Myelodysplastic syndromes (MDSs) are myeloid malignancies often driven by mutations in genes encoding splicing factors (SFs). How these mutations drive the clonal expansion of MDS stem/progenitor cells to outcompete normal hematopoietic stem/progenitor cells (HSPCs) remains unexplained. Although a role for inflammatory processes in promoting clonal expansion of mutant HSPCs and MDS pathogenesis has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40163808
DOI: 10.1182/blood.2024025670
PMCID: PMC12290515

Genes

SRSF2
STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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