Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

doi:10.1016/j.ccell.2018.07.003

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Article

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Cancer cell - 13 Aug 2018

Lee Stanley Chun-Wei, North Khrystyna, Kim Eunhee, Jang Eunjung, Obeng Esther, Lu Sydney X, Liu Bo, Inoue Daichi, Yoshimi Akihide, Ki Michelle, Yeo Mirae, Zhang Xiao Jing, Kim Min Kyung, Cho Hana, Chung Young Rock, Taylor Justin, Durham Benjamin H, Kim Young Joon, Pastore Alessandro, Monette Sebastien, Palacino James, Seiler Michael, Buonamici Silvia, Smith Peter G, Ebert Benjamin L, Bradley Robert K, Abdel-Wahab Omar

Abstract excerpt

Mutations affecting RNA splicing factors are the most common genetic alterations in myelodysplastic syndrome (MDS) patients and occur in a mutually exclusive manner. The basis for the mutual exclusivity of these mutations and how they contribute to MDS is not well understood. Here we report that although different spliceosome gene mutations impart distinct effects on splicing, they are negatively selected for...

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Identifiers

PMID: 30107174
DOI: 10.1016/j.ccell.2018.07.003
PMCID: PMC6373472

Genes

SRSF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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