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Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctions

26 Sept 2022

Abstract excerpt

Two human natural anti-carbohydrate antibodies appeared in critical evolutionary events that brought primates and hominins to brink of extinction. The first is the anti-Gal antibody, produced in Old-World monkeys (OWM), apes and humans. It binds the carbohydrate-antigen 'α-gal epitope' (Galα1-3Galβ1-4GlcNAc-R) on carbohydrate-chains (glycans) synthesized by non-primate mammals, lemurs and New-World monkeys (NWM)....

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PMID: 36161654
DOI: 10.1111/imm.13582

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