Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective

Abstract excerpt

The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-Glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-Acetylneuraminic acid (Neu5Ac). Most humans also have circulating antibodies specifically targeting the non-human sialic acid Neu5Gc. Recently, several additional mammalian species have been found to also lack Neu5Gc. In all cases,...

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