Article
Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity.
Human genetics - 1 Jun 2020
Le Pendu Jacques, Ruvoën-Clouet Nathalie
Abstract excerpt
Together, norovirus and rotavirus are responsible for the majority of gastroenteritis cases worldwide, leading to a large number of deaths of children in low-income countries. Both attach to glycans of the histo-blood group antigen type (HBGAs) widely expressed in the digestive tract of vertebrates, albeit with interspecies differences. In humans, their synthesis is performed by glycosyltransferases encoded by...
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