Article

The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex

2026-03-12

Abstract excerpt

Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in TSC1 and TSC2, resulting in activation of mechanistic target of rapamycin complex 1 (mTORC1). Neurological manifestations in TSC patients include epilepsy, autism and intellectual disability. Two types of brain lesions, cortical tubers and subependymal giant cell astrocytomas (SEGAs), cause the majority of neurological manifestations in TS...

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Literature Corpus work: f00e51f3-b764-5be5-9afb-1a1abbce0c18
DOI: 10.64898/2026.03.10.698104

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