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Article

KIF2C promotes paclitaxel resistance by depolymerizing polyglutamylated microtubules

31 Mar 2025

Abstract excerpt

The long-term effectiveness of paclitaxel is limited by chemoresistance. In this study, we elucidate the molecular mechanism by which kinesin family member 2C (KIF2C), a well-known microtubule depolymerase, contributes to the development of chemoresistance in triple-negative breast cancer (TNBC). We observed elevated levels of KIF2C, tubulin tyrosination, and polyglutamylation in human and mouse breast cancer...

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PMID: 40157365
DOI: 10.1016/j.devcel.2025.03.004

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