Article

MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models

2023-06-01

Abstract excerpt

Standard of care for triple negative breast cancer (TNBC) involves the use of microtubule poisons like paclitaxel, which are proposed to work by inducing lethal levels of aneuploidy in tumor cells. While these drugs are initially effective in treating cancer, dose-limiting peripheral neuropathies are common. Unfortunately, patients often relapse with drug resistant tumors. Identifying agents against targets that l...

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Literature Corpus work: 9b0c30c1-e677-51f6-8da8-8d46b63cc918
DOI: 10.20944/preprints202306.0109.v1

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