Article
Deciphering SARS-CoV-2 evolution under antibody immune pressure.
Trends in immunology - 1 Apr 2025
Jian Fanchong, Cao Yunlong
Abstract excerpt
The ongoing evolution of SARS-CoV-2 poses significant challenges to existing neutralizing antibodies and vaccines through immune escape mutations. By leveraging genomic surveillance and antibody deep mutational scanning (DMS) data, Raharinirina and colleagues developed a computational framework to elucidate region-specific SARS-CoV-2 variant dynamics and predict evolutionary trends under population immunity.
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