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Article

In vitro isolation of contemporary Treponema pallidum strains directly from clinical samples of syphilis patients

26 Mar 2025

Abstract excerpt

Objectives Treponema pallidum subsp. pallidum ( T. pallidum ) is the etiological agent of syphilis, a sexually transmitted disease of global public health importance. The objective of this study was to introduce a novel in vitro protocol for isolation of T. pallidum directly from patients' clinical samples, eliminating the need for rabbit propagation. Methods Four oral and five genital swabs were collected from...

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PMID: 40147590
DOI: 10.1016/j.cmi.2025.03.017

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