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Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

24 Jan 2025

Abstract excerpt

For over a century, Treponema pallidum subsp. pallidum, the spiral-shaped bacterium that causes syphilis, could only be propagated by inoculation and harvest of the organisms from rabbit testes. In 2018, we described a method to continuously cultivate T. pallidumin vitro. This system utilizes co-culture with rabbit epithelial cells (Sf1Ep cells) in a serum-containing tissue culture medium called TpCM-2. The T....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39927652
DOI: 10.3791/66880

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