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Article

Sendotypes predict worsening renal function in chronic kidney disease patients.

Clinical and translational medicine - 1 Apr 2025

McLarnon Thomas, Watterson Steven, McCallion Sean, Cooper Eamonn, English Andrew R, Kuan Ying, Gibson David S, Murray Elaine K, McCarroll Frank, Zhang Shu-Dong, Bjourson Anthony J, Rai Taranjit Singh

Abstract excerpt

BACKGROUND: Senescence associated secretory phenotype (SASP) contributes to age-related pathology, however the role of SASP in Chronic Kidney Disease (CKD) is unclear. Here, we employ a variety of omic techniques to show that senescence signatures can separate CKD patients into distinct senescence endotypes (Sendotype). METHODS: Using specific numbers of senescent proteins, we clustered CKD patients into two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40147025
DOI: 10.1002/ctm2.70279
PMCID: PMC11949504

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TNF

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