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Association of ESR1, HER1, and HER2 Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study.

Journal of mammary gland biology and neoplasia - 27 Mar 2025

Khan Najeeb Ullah, Khan Hamza, Alanzi Abdullah R, Chen Tianhui

Abstract excerpt

Breast cancer is a complex disease characterized by the uncontrolled growth of breast cells. Genetic variants in ESR1, HER1, and HER2 have been associated with breast cancer risk across different populations, with varying results. This study aimed to validate the association of ESR1 (rs2234693 and rs2046210), HER1 (rs11543848), and HER2 (rs1136201) variants with breast cancer risk in the KP population of Pakistan...

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Aged
Alleles
Breast Neoplasms
Case-Control Studies
Erb-b2 Receptor Tyrosine Kinases
Estrogen Receptor alpha
Pakistan
Risk Factors

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Open in PubMed Open full text

Identifiers

PMID: 40146396
DOI: 10.1007/s10911-025-09581-9
PMCID: PMC11950110

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Association of ESR1, HER1, and HER2 Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study.PMID 40146396Read ↗

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