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Unique ESR1 and ESR2 estrogen receptor gene variants associated with altered risk of triple-negative breast cancer: A case-control study.

Gene - 30 Jan 2023

Sghaier Ikram, Zidi Sabrina, El-Ghali Rabeb M, Daldoul Amira, Aimagambetova Gulzhanat, Almawi Wassim Y

Abstract excerpt

BACKGROUND: We previously reported on the association between ESR1 and ESR2 gene variants and heightened risk of breast cancer (BC). Here we investigated the association of common ESR1 and ESR2 gene variants with triple negative BC (TNBC). METHODS: This retrospective case-control study involved 488 BC patients (130 TNBC, 358 non-TNBC patients). ESR1 (rs2234693, rs9340799, rs3020314, rs3798577) and ESR2 (rs928554,...

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PMID: 36261089
DOI: 10.1016/j.gene.2022.146969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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