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Article

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

25 Mar 2025

Abstract excerpt

Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate immune cells to shape protective host defense mechanisms remains unknown. Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory....

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PMID: 40133533
DOI: 10.1038/s44320-025-00093-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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