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Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity.

Human vaccines & immunotherapeutics - 31 Dec 2024

Hsieh Min-Jia, Tsai Ping-Hsing, Chiang Pin-Hsuan, Kao Zih-Kai, Zhuang Zi-Qing, Hsieh Ai-Ru, Ho Hsiang-Ling, Chiou Shih-Hwa, Liang Kung-Hao, Chen Yu-Chun

Abstract excerpt

Genetic polymorphisms have been linked to the differential waning of vaccine-induced immunity against COVID-19 following vaccination. Despite this, evidence on the mechanisms behind this waning and its implications for vaccination policy remains limited. We hypothesize that specific gene variants may modulate the development of vaccine-initiated immunity, leading to impaired immune function. This study...

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Identifiers

PMID: 39254005
DOI: 10.1080/21645515.2024.2399382
PMCID: PMC11404610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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