The diagnostic value of comprehensive next-generation sequencing for genetic mutations in suspected lung cancer cases with negative pathological cytology.

doi:10.1016/j.lungcan.2025.108505

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Article

The diagnostic value of comprehensive next-generation sequencing for genetic mutations in suspected lung cancer cases with negative pathological cytology.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2025

Goto Yuka, Watanabe Satoshi, Yanagimura Naohiro, Arita Masashi, Sato Miyuki, Nozaki Koichiro, Tanaka Tomohiro, Saida Yu, Maemondo Makoto, Kobayashi Kunihiko, Hagiwara Koichi, Kikuchi Toshiaki

Abstract excerpt

INTRODUCTION: In recent clinical practice, driver gene mutations have been tested using multiplex PCR or next-generation sequencing (NGS), which help determine treatment strategies for non-small cell lung cancer (NSCLC). We developed a new analysis system, the Mutation Investigator using Next-era Sequencer (MINtS), using NGS, which allows for the detection of gene mutations even in cytology specimens with low...

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Topics

Humans
Lung Neoplasms
High-Throughput Nucleotide Sequencing
Male
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Middle Aged

Aged

Carcinoma, Non-Small-Cell Lung

Retrospective Studies

Adult

Prospective Studies

Aged, 80 and over

DNA Mutational Analysis

Cytodiagnosis

Source

Open in PubMed

Identifiers

PMID: 40117845
DOI: 10.1016/j.lungcan.2025.108505

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