Article
Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.
International journal of oncology - 1 May 2017
Yamamoto Gou, Kikuchi Mari, Kobayashi Shiho, Arai Yoshiko, Fujiyoshi Kenji, Wakatsuki Tomokazu, Kakuta Miho, Yamane Yuki, Iijima Yoshihito, Mizutani Hideaki, Nakajima Yuki, Sudo Junko, Kinoshita Hiroyasu, Kurimoto Futoshi, Akiyama Hirohiko, Uramoto Hidetaka, Sakai Hiroshi, Akagi Yoshito, Akagi Kiwamu
Abstract excerpt
After the development of EGFR tyrosine kinase inhibitors (TKIs), genetic testing of EGFR became required for effective treatment of lung cancer. Initially, the testing was conducted separately for each mutated region. However, many EGFR mutations have since been identified that determine the efficacy of EGFR-TKIs. Therefore, genetic testing of EGFR by next generation sequencing (NGS) may be a suitable strategy...
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