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Article

A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer.

PloS one - 1 Jan 2017

Inoue Yoshiaki, Shiihara Jun, Miyazawa Hitoshi, Ohta Hiromitsu, Higo Megumi, Nagai Yoshiaki, Kobayashi Kunihiko, Saijo Yasuo, Tsuchida Masanori, Nakayama Mitsuo, Hagiwara Koichi

Abstract excerpt

Molecular targeting therapy for non-small cell lung cancer (NSCLC) has clarified the importance of mutation testing when selecting treatment regimens. As a result, multiple-gene mutation tests are urgently needed. We developed a next-generation sequencer (NGS)-based, multi-gene test named the MINtS for investigating driver mutations in both cytological specimens and snap-frozen tissue samples. The MINtS was used...

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Identifiers

PMID: 28448556
DOI: 10.1371/journal.pone.0176525
PMCID: PMC5407820

Genes

EGFR
ALK
BRAF
ERBB2
KRAS
RET
ROS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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