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Article

Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.

Investigative ophthalmology & visual science - 3 Mar 2025

Ouyang Pingbo, Qi Jia, Tong Boding, Li Yunping, Cao Jiamin, Wang Lujue, Niu Tongxin, Qi Xin

Abstract excerpt

Purpose: Graves' orbitopathy (GO), the common extrathyroidal complication of Graves' disease (GD), is characterized by orbital fibroblast stimulation, adipogenesis, and hyaluronan production. Recently, gut microbiota and its metabolites have garnered attention for their possible involvement in GO. Methods: This study utilized an animal model of GO and examined the effects of butyrate treatment on orbital...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40035727
DOI: 10.1167/iovs.66.3.5
PMCID: PMC11892527

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GCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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