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DNA methylation heterogeneity correlates with field cancerization and prognosis in lung adenocarcinoma patients

20 Mar 2025

Abstract excerpt

BACKGROUND: Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. The distinctive genetic and epigenetic modifications in tumors and paired non-malignant samples, such as adjacent peri-tumor and tumor-distant normal lung tissues, have not been adequately studied. METHODS: We recruited 57 patients with resectable stage I-III LUAD and collected matched samples of the primary tumor,...

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Share to Epigenetics and DNA Methylation
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PMID: 40114223
DOI: 10.1186/s13148-025-01845-9

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