Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma

19 Mar 2025

Abstract excerpt

The KIT/c-KIT proto-oncogene is frequently over-expressed in Merkel cell carcinoma (MCC), an aggressive skin cancer commonly caused by Merkel cell polyomavirus (MCPyV). Here, we demonstrated that truncated MCPyV-encoded large T-antigen (LT) suppressed macroautophagy/autophagy by stabilizing and sequestering KIT in the paranuclear compartment via binding VPS39. KIT engaged with phosphorylated BECN1, thereby...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Energy Harvesting in Wireless Networks
Share to Plant Virus Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40108758
DOI: 10.1080/15548627.2025.2477385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinomaPMID 40108758Read ↗

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genesSemantic proximity Read ↗

Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.Semantic proximity Read ↗

Merkel Cell Polyomavirus Large T Antigen Disrupts Host Genomic Integrity and Inhibits Cellular ProliferationSemantic proximity Read ↗

Regulation of Autophagy in Cells Infected With Oncogenic Human Viruses and Its Impact on Cancer DevelopmentSemantic proximity Read ↗

Merkel Cell Polyomavirus: Oncogenesis in a Stable GenomeSemantic proximity Read ↗

Delta-catenin is required for cell proliferation in virus positive Merkel cell carcinoma cell lines but not in human fibroblastsSemantic proximity Read ↗

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCPSemantic proximity Read ↗

Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the NucleusSemantic proximity Read ↗

Huntingtin-Interacting Protein 1: A Merkel Cell Carcinoma Marker that Interacts with c-KitSemantic proximity Read ↗

The Role of the Large T Antigen in the Molecular Pathogenesis of Merkel Cell CarcinomaSemantic proximity Read ↗

Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistenceSemantic proximity Read ↗

Oncogenic Merkel Cell Polyomavirus T Antigen Truncating Mutations are Mediated by APOBEC3 Activity in Merkel Cell Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.