Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the Nucleus

17 Mar 2011

Abstract excerpt

Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVam6p cytoplasmic protein involved in lysosomal processing as a novel interactor with MCV LT but not SV40 LT. hVam6p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Full-Duplex Wireless Communications
Share to Plant Virus Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21454559
DOI: 10.1074/jbc.m110.192856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the NucleusPMID 21454559Read ↗

Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinomaSemantic proximity Read ↗

Infectious Entry of Merkel Cell PolyomavirusSemantic proximity Read ↗

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genesSemantic proximity Read ↗

Cellular v-ATPase is required for virion assembly compartment formation in human cytomegalovirus infectionSemantic proximity Read ↗

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCPSemantic proximity Read ↗

Nuclear localization of Merkel cell polyomavirus large T antigen in Merkel cell carcinomaSemantic proximity Read ↗

Huntingtin-Interacting Protein 1: A Merkel Cell Carcinoma Marker that Interacts with c-KitSemantic proximity Read ↗

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenanceSemantic proximity Read ↗

The Small Tumor Antigen of Merkel Cell Polyomavirus Accomplishes Cellular Transformation by Uniquely Localizing to the Nucleus Despite the Absence of a Known Nuclear Localization SignalSemantic proximity Read ↗

Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T AntigenSemantic proximity Read ↗

Cellular and viral factors regulating Merkel cell polyomavirus replication.Semantic proximity Read ↗

Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.