Article
Comparison of Akt/mTOR/4E-BP1 pathway signal activation and mutations of PIK3CA in Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative carcinomas.
Human pathology - 1 Feb 2015
Iwasaki Takeshi, Matsushita Michiko, Nonaka Daisuke, Kuwamoto Satoshi, Kato Masako, Murakami Ichiro, Nagata Keiko, Nakajima Hideki, Sano Shigetoshi, Hayashi Kazuhiko
Abstract excerpt
Merkel cell polyomavirus (MCPyV) integrates monoclonally into the genomes of approximately 80% of Merkel cell carcinomas (MCCs), affecting their clinicopathological features. The molecular mechanisms underlying MCC development after MCPyV infection remain unclear. We investigated the association of MCPyV infection with activation of the Akt/mammalian target of rapamycin (mTOR)/4E-binding protein 1 (4E-BP1)...
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