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Article

Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.

Cell reports - 5 Jan 2021

Hughes Robert O, Bosanac Todd, Mao Xianrong, Engber Thomas M, DiAntonio Aaron, Milbrandt Jeffrey, Devraj Rajesh, Krauss Raul

Abstract excerpt

Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process can generate a metastable pool of damaged axons that remain structurally and functionally viable but fated to degenerate in the absence of external intervention. SARM1, an NADase that depletes axonal energy stores upon activation, is the central driver of...

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Identifiers

PMID: 33406435
DOI: 10.1016/j.celrep.2020.108588
PMCID: PMC8179325

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Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.PMID 33406435Read ↗

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