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Article

Soluble Fms-like tyrosine kinase-1 polymorphisms associated with severe-spectrum hypertensive disorders of pregnancy.

Archives of gynecology and obstetrics - 1 Mar 2025

Chen Tracy, Baldauf Claire E, Gill Kevin S, Ingles Sue Ann, Pickering Trevor A, Wilson Melissa L

Abstract excerpt

BACKGROUND: sFLT-1 has been implicated in the pathogenesis of HDP. We aimed to examine the role of maternal and fetal polymorphisms in risk of HDP and severe-spectrum disease. METHODS: Cases of HDP (143) and controls (169) from mother-baby dyads were recruited at the Los Angeles County Women's and Children's Hospital (WCH). Cases of severe disease (99) and controls (31) from mother-father-baby triads were...

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Identifiers

PMID: 39806130
DOI: 10.1007/s00404-024-07917-0
PMCID: PMC11920004

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