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Article

Formin 3 stabilizes the cytoskeleton of Drosophila tendon cells, thus enabling them to resist muscle tensile forces.

Journal of cell science - 1 Apr 2025

Pissarek Helena, Huang Na, Frasch Leanna H, Aberle Hermann, Frasch Manfred

Abstract excerpt

The cytoskeleton of Drosophila tendon cells features specialized F-actin and microtubule arrays that endow these cells with resistance to the tensile forces exerted by the attached muscles. In a forward genetic screen for mutants with neuromuscular junction and muscle morphology phenotypes in larvae, we identified formin 3 (form3) as a crucial component for stabilizing these cytoskeletal arrays under muscle...

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Topics

Animals
Drosophila Proteins
Microtubules
Formins
Cytoskeleton
Microfilament Proteins
Tendons

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drosophila melanogaster

Tensile Strength

Actins

Muscles

Actin Cytoskeleton

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40084430
DOI: 10.1242/jcs.263543
PMCID: PMC12045603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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