The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.

doi:10.1038/ng.3602

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.

Nature genetics - 1 Aug 2016

Gibson William J, Hoivik Erling A, Halle Mari K, Taylor-Weiner Amaro, Cherniack Andrew D, Berg Anna, Holst Frederik, Zack Travis I, Werner Henrica M J, Staby Kjersti M, Rosenberg Mara, Stefansson Ingunn M, Kusonmano Kanthida, Chevalier Aaron, Mauland Karen K, Trovik Jone, Krakstad Camilla, Giannakis Marios, Hodis Eran, Woie Kathrine, Bjorge Line, Vintermyr Olav K, Wala Jeremiah A, Lawrence Michael S, Getz Gad, Carter Scott L, Beroukhim Rameen, Salvesen Helga B

Abstract excerpt

Recent studies have detailed the genomic landscape of primary endometrial cancers, but the evolution of these cancers into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex atypical hyperplasias, primary tumors and paired abdominopelvic metastases to survey the evolutionary landscape of endometrial cancer. We expanded and reanalyzed The Cancer Genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abdominal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Disease Progression

Share to Endometrial Hyperplasia

Share to Endometrial Neoplasms

Share to Exome

Share to Genomics

Share to High-Throughput Nucleotide Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 27348297
DOI: 10.1038/ng.3602
PMCID: PMC4963271

Genes

NRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.PMID 27348297Read ↗

The mutational landscape of endometrial cancer.Semantic proximity Read ↗

The genomic landscape of distant metastatic endometrial cancer.Semantic proximity Read ↗

Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma.Semantic proximity Read ↗

Comprehensive Molecular Characterization of High-Grade Endometrial Cancer in an Ancestrally-Diverse CohortSemantic proximity Read ↗

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.Semantic proximity Read ↗

Distinct Genomic Landscapes in Early-Onset and Late-Onset Endometrial Cancer.Semantic proximity Read ↗

Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression.Semantic proximity Read ↗

Next-Generation Sequencing.Semantic proximity Read ↗

Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation SequencingSemantic proximity Read ↗

Genome-wide mutation analysis in precancerous lesions of endometrial carcinoma.Semantic proximity Read ↗

Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinomaSemantic proximity Read ↗

Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.