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Article

Multi-Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14 086 Japanese Individuals.

Journal of the American Heart Association - 18 Mar 2025

Fujii Ryosuke, Nagayoshi Mako, Nakatochi Masahiro, Sato Shuntaro, Tsuboi Yoshiki, Suzuki Koji, Ikezaki Hiroaki, Nishida Yuichiro, Kubo Yoko, Tanoue Shiroh, Suzuki Sadao, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Katsuura-Kamano Sakurako, Momozawa Yukihide, Wakai Kenji, Matsuo Keitaro

Abstract excerpt

BACKGROUND: Although utility of composite trait-specific polygenic risk score (multi-trait PRS) has been examined among European ancestries, few studies investigated among East Asians and incorporated modifiable risk factors. We examined the associations of multi-trait PRS for cardiometabolic factors with cardiovascular disease mortality by integrating nongenetic determinants. METHODS: A total of 14 086 Japanese...

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Identifiers

PMID: 40079315
DOI: 10.1161/JAHA.124.038572
PMCID: PMC12132758

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