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Polygenic Risk Score, Cardiorespiratory Fitness, and Cardiometabolic Risk Factors: WASEDA'S Health Study.

Medicine and science in sports and exercise - 1 Oct 2024

Tanisawa Kumpei, Tabata Hiroki, Nakamura Nobuhiro, Kawakami Ryoko, Usui Chiyoko, Ito Tomoko, Kawamura Takuji, Torii Suguru, Ishii Kaori, Muraoka Isao, Suzuki Katsuhiko, Sakamoto Shizuo, Higuchi Mitsuru, Oka Koichiro

Abstract excerpt

PURPOSE: This study estimated an individual's genetic liability to cardiometabolic risk factors by polygenic risk score (PRS) construction and examined whether high cardiorespiratory fitness (CRF) modifies the association between PRS and cardiometabolic risk factors. METHODS: This cross-sectional study enrolled 1296 Japanese adults aged ≥40 yr. The PRS for each cardiometabolic trait (blood lipids, glucose,...

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PMID: 38768052
DOI: 10.1249/MSS.0000000000003477
PMCID: PMC11419280

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