Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a multifactorial, hypertrophic, and degenerative condition involving the whole joint and affecting a high percentage of middle-aged people. It is due to a combination of factors, although the pivotal mechanisms underlying the disease are still obscure. Moreover, current treatments are still poorly effective, and patients experience a painful and degenerative disease course....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bioinformatics and Genomic Networks
• Share to Osteoarthritis Treatment and Mechanisms
• Share to Rheumatoid Arthritis Research and Therapies