Association of catechol-O-methyltransferase genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence.

doi:10.1016/j.ajog.2025.03.007

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Article

Association of catechol-O-methyltransferase genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence.

American journal of obstetrics and gynecology - 1 Sept 2025

Florian-Rodriguez Maria E, Richter Holly E, Carnes Megan U, Zyczynski Halina, Lukacz Emily S, Visco Anthony, Arya Lily, Sung Vivian, Mazloomdoost Donna, Gantz Marie G

Abstract excerpt

BACKGROUND: Prior studies have failed to demonstrate clinical or statistical difference in fecal incontinence (FI) symptom improvement with neuromodulation by percutaneous tibial nerve stimulation vs sham. The results of these studies may be indicative of a placebo or sham effect and led us to investigate possible genetic biomarkers of placebo response among women with FI. OBJECTIVE: To evaluate the relationship...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 40073917
DOI: 10.1016/j.ajog.2025.03.007
PMCID: PMC12353591

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