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Article

Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia.

American journal of obstetrics and gynecology - 1 Apr 2017

Patanwala Insiyyah Y, Lamvu Georgine, Ledger William J, Witzeman Kathryn, Marvel Richard, Rapkin Andrea, Bongiovanni Ann Marie, Feranec Jessica, Witkin Steven S

Abstract excerpt

BACKGROUND: The underlying causes of vulvar pain in women with vulvodynia remain poorly understood. Catechol-O-methyltransferase, an enzyme that metabolizes catecholamines, is a neuromodulator that is involved with perception and sensitivity to pain. The catechol-O-methyltransferase gene is polymorphic, and a single nucleotide polymorphism is associated with low activity and heightened pain sensitivity. The...

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PMID: 27780702
DOI: 10.1016/j.ajog.2016.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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