Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants.

doi:10.2217/epi-2020-0021

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Article

Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants.

Epigenomics - 1 Oct 2020

Cáceres-Rojas Gabriela, Salamanca Carlos, Krause Bernardo J, Recabarren Andrea S, Recabarren Pamela A, Pantoja Roberto, Leiva Noemi, Pardo Rosa, Santos José Luis, Suazo José

Abstract excerpt

Aim: To evaluate the risk of nonsyndromic orofacial clefts (NSOFCs) associated with LINE-1 methylation, as a marker of global DNA methylation, and the effect of MTHFR functional variants on this variable. Patients & methods: LINE-1 methylation was evaluated by bisulfite modification coupled to DNA pyrosequencing in 95 NSOFC cases and 95 controls. In these subjects, MTHFR genotypes for variants c.C677T (rs1801133)...

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PMID: 33147056
DOI: 10.2217/epi-2020-0021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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