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Article

Neanderthal adaptive introgression shaped LCT enhancer region diversity without linking to lactase persistence in East Asian populations.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2025

Ma Xixian, Lu Yan, Stoneking Mark, Xu Shuhua

Abstract excerpt

Positive selection at the 2q21.3 enhancer region for lactase gene (LCT) expression in Europeans and Africans has long been attributed to selection for lactase persistence (LP), the capacity of adults to digest lactose in milk, presumably because of the benefits associated with milk consumption. While considered a classic example of gene-culture coevolution, recently doubts have been raised about the link between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40063818
DOI: 10.1073/pnas.2404393122
PMCID: PMC11929401

Genes

LCT
DARS1
UBXN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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