Article
Convergent adaptation of human lactase persistence in Africa and Europe.
Nature genetics - 1 Jan 2007
Tishkoff Sarah A, Reed Floyd A, Ranciaro Alessia, Voight Benjamin F, Babbitt Courtney C, Silverman Jesse S, Powell Kweli, Mortensen Holly M, Hirbo Jibril B, Osman Maha, Ibrahim Muntaser, Omar Sabah A, Lema Godfrey, Nyambo Thomas B, Ghori Jilur, Bumpstead Suzannah, Pritchard Jonathan K, Wray Gregory A, Deloukas Panos
Abstract excerpt
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010, T/G-13915 and C/G-13907) that are associated with lactase...
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