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Article

The molecular basis of lactase persistence: Linking genetics and epigenetics.

Annals of human genetics - 1 Sept 2025

Cohen Céleste E, Swallow Dallas M, Walker Catherine

Abstract excerpt

Lactase persistence (LP) - the genetic trait that determines the continued expression of the enzyme lactase into adulthood - has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations. While underlying evolutionary explanations have been widely posited and studied, the molecular basis of LP remains less so. This review considers the genetic and...

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Topics

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Share to DNA Methylation
Share to Enhancer Elements, Genetic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ETS1 gene

Share to GATA6 gene

Share to Lactase

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 39171584
DOI: 10.1111/ahg.12575
PMCID: PMC12336946

Genes

LCT
ETS1
FOXA1
GATA6
MCM6
POU2F1
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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