Article
Herders of Indian and European cattle share their predominant allele for lactase persistence.
Molecular biology and evolution - 1 Jan 2012
Gallego Romero Irene, Basu Mallick Chandana, Liebert Anke, Crivellaro Federica, Chaubey Gyaneshwer, Itan Yuval, Metspalu Mait, Eaaswarkhanth Muthukrishnan, Pitchappan Ramasamy, Villems Richard, Reich David, Singh Lalji, Thangaraj Kumarasamy, Thomas Mark G, Swallow Dallas M, Mirazón Lahr Marta, Kivisild Toomas
Abstract excerpt
Milk consumption and lactose digestion after weaning are exclusively human traits made possible by the continued production of the enzyme lactase in adulthood. Multiple independent mutations in a 100-bp region--part of an enhancer--approximately 14-kb upstream of the LCT gene are associated with this trait in Europeans and pastoralists from Saudi Arabia and Africa. However, a single mutation of purported western...
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