Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.

doi:10.1016/j.ajhg.2013.07.008

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Article

Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.

American journal of human genetics - 5 Sept 2013

Jones Bryony L, Raga Tamiru O, Liebert Anke, Zmarz Pawel, Bekele Endashaw, Danielsen E Thomas, Olsen Anders Krüger, Bradman Neil, Troelsen Jesper T, Swallow Dallas M

Abstract excerpt

The persistent expression of lactase into adulthood in humans is a recent genetic adaptation that allows the consumption of milk from other mammals after weaning. In Europe, a single allele (-13910(∗)T, rs4988235) in an upstream region that acts as an enhancer to the expression of the lactase gene LCT is responsible for lactase persistence and appears to have been under strong directional selection in the last...

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PMID: 23993196
DOI: 10.1016/j.ajhg.2013.07.008
PMCID: PMC3769926

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