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Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians

10 Mar 2025

Abstract excerpt

Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into mechanisms promoting high physical function with aging, we performed proteomics, targeted metabolomics, and targeted kynurenine-focused metabolomic analyses on serum specimens from three groups of octogenarians:...

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PMID: 40059508
DOI: 10.1111/acel.70002

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