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Article

Association of plasma gelsolin with frailty phenotype and mortality among octogenarian community-dwelling men: a cohort study.

Aging clinical and experimental research - 1 May 2022

Strandberg Timo E, Levinson Susan L, DiNubile Mark J, Jyväkorpi Satu, Kivimäki Mika

Abstract excerpt

BACKGROUND: Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. AIMS: To investigate whether pGSN could be a biomarker of the frailty phenotype and predict mortality. METHODS: A homogenous cohort of males (born 1919-1934, baseline n = 3490) has been followed since the...

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Identifiers

PMID: 35169987
DOI: 10.1007/s40520-022-02083-2
PMCID: PMC9135837

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