Back to search

Article

Molecular Biomarkers of Training Maladaptation: A Multi-Omics Roadmap from Functional Overreaching to Overtraining Syndrome

2026-03-27

Abstract excerpt

Exercise adaptation depends on overload that is resolved by recovery, yet the same biology becomes maladaptive when immune, endocrine, metabolic, and muscle-centered stress signals fail to normalize. Exercise-induced maladaptation represents a systems-level failure of biological resolution, with direct relevance to disease-like dysregulation. Functional overreaching, non-functional overreaching, and overtraining s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
16cbf9f9-fa81-5f9c-95a1-2b414318c2cb
DOI
10.20944/preprints202603.2183.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular Biomarkers of Training Maladaptation: A Multi-Omics Roadmap from Functional Overreaching to Overtraining SyndromeDOI 10.20944/preprints202603.2183.v1
From Adaptation to Exhaustion: Defining Exposure-Related Malnutrition as a Bioenergetic Phenotype of AgingSemantic proximity
From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging.Semantic proximity
Temporal dynamics of the multi-omic response to endurance exercise training across tissuesSemantic proximity
Molecular Choreography of Acute ExerciseSemantic proximity
Energy Allocation Resilience and Endocrine IntegrationSemantic proximity
A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited reviewSemantic proximity
Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)Semantic proximity
Transcriptomic meta‐analysis of disuse muscle atrophy vs. resistance exercise‐induced hypertrophy in young and older humansSemantic proximity
Integrated Single-Fiber Multi-Omics Links an Inflammatory-Associated Myofiber State to Altered Myosin Dynamics in Patients with ICU-acquired weaknessSemantic proximity
Three months of bed rest induce a residual transcriptomic signature resilient to resistance exercise countermeasuresSemantic proximity
Temporal Multi-Omic Analysis Uncovers Sex-Biased Molecular Programs Underlying Skeletal Muscle Adaptation to Endurance TrainingSemantic proximity
Body Fluid Proteomic Landscape of Acute ExerciseSemantic proximity
Select a neighboring publication to make it the new centre.