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Ferroptosis in life: To be or not to be

10 Jan 2023

Abstract excerpt

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria and aberrant accumulation of excessive iron as well as loss of the cysteine-glutathione-GPX4 axis. Eventually, the accumulated lipid peroxides result in lethal damage to the cells. Ferroptosis is induced by the overloading of iron and...

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PMID: 36634587
DOI: 10.1016/j.biopha.2023.114241

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