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Insight into the Double-Edged Role of Ferroptosis in Disease

30 Nov 2021

Abstract excerpt

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis,...

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PMID: 34944434
DOI: 10.3390/biom11121790

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